HIST1H1C | Histone H1.2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
HIST1H1C
Synonyms
H1F2
Protein Name
Histone H1.2
UniProt ID
P16403 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000339566
NCBI Gene ID
3006
Molecular Weight
21365
Protein Length
213
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Chromosome;
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Gene Ontology
GO:0005719; GO:0000786; GO:0005634; GO:0035327; GO:0031490; GO:0003690; GO:0031492; GO:0003723; GO:0030261; GO:0098532; GO:0080182; GO:0031936; GO:0045910; GO:0000122; GO:0006334; GO:0016584; GO:0006355
 
Gene Ontology