Protein Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
114757
Protein Length
1042
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate
Localization
Endoplasmic reticulum membrane,Sarcoplasmic reticulum membrane;
Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
Gene Ontology
GO:0061831; GO:0090534; GO:0005783; GO:0005789; GO:0031234; GO:0005887; GO:0014801; GO:0016020; GO:0005654; GO:0048471; GO:0120025; GO:0031095; GO:0032991; GO:0097470; GO:0016529; GO:0033017; GO:0012506; GO:0005524; GO:0005509; GO:0005388; GO:0086039; GO:0019899; GO:0031775; GO:0008022; GO:0008553; GO:0044548; GO:1990036; GO:0070588; GO:1903515; GO:0014898; GO:0007155; GO:0006874; GO:0034605; GO:0034599; GO:0032469; GO:0008544; GO:0006984; GO:0034220; GO:0045822; GO:0006996; GO:0032470; GO:0010460; GO:1903233; GO:1903779; GO:0098909; GO:0086036; GO:0010882; GO:0002026; GO:0055119; GO:0034976; GO:0032496; GO:0070296; GO:0003009; GO:0033292; GO:0014883