CaMKinet | Result

Gene

Spr

Synonyms

Protein Name

Sepiapterin reductase

UniProt ID

P18297 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSRNOP00000020749

NCBI Gene ID

29270

Molecular Weight

28128

Protein Length

262

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

1.1.1.153; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH

Localization

Cytoplasm;

Function

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Gene Ontology

GO:0005737; GO:0004757; GO:0010033; GO:0006729