CaMKinet | Result

Gene

GABRG2

Synonyms

Protein Name

Gamma-aminobutyric acid receptor subunit gamma-2

UniProt ID

P18507-2 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000410732

NCBI Gene ID

2566

Molecular Weight

54162

Protein Length

467

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 6d6t)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell junction,Synapse,Postsynaptic cell membrane,Cell membrane,Cell projection,Dendrite,Cytoplasmic vesicle membrane;

Function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Gene Ontology

GO:0030424; GO:0030054; GO:0034707; GO:0030659; GO:0032590; GO:1902711; GO:0098982; GO:0005887; GO:0043005; GO:0005886; GO:0098794; GO:0045211; GO:0045202; GO:0008503; GO:0005254; GO:0004890; GO:0022851; GO:0005237; GO:1904315; GO:0030534; GO:0071420; GO:0007268; GO:1902476; GO:0007214; GO:0034220; GO:0050877; GO:0009791; GO:0042391; GO:0060078; GO:0007165; GO:0051932