Protein Name
Cofilin-1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
18560
Protein Length
166
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus matrix,Cytoplasm,Cytoskeleton,Cell projection,Ruffle membrane,Cell projection,Lamellipodium membrane,Cell projection,Lamellipodium;
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11809832). Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (PubMed:15649475).
Gene Ontology
GO:0031252; GO:0005911; GO:0090732; GO:0030864; GO:0005737; GO:0005829; GO:0043197; GO:0005576; GO:0005615; GO:0030175; GO:0098978; GO:0030426; GO:0030027; GO:0031258; GO:0031966; GO:0043005; GO:0043025; GO:0016363; GO:0032587; GO:0097060; GO:0003779; GO:0051015; GO:1902936; GO:0019903; GO:0005102; GO:0030042; GO:0030043; GO:0007015; GO:0030030; GO:0071364; GO:0071362; GO:0070301; GO:1990314; GO:0071347; GO:0071354; GO:0071356; GO:0007010; GO:0030010; GO:0021766; GO:0000281; GO:0098885; GO:0032232; GO:0030835; GO:0007162; GO:2000146; GO:0045792; GO:1902951; GO:0010593; GO:1905875; GO:0051511; GO:0001755; GO:0001842; GO:0044794; GO:0030836; GO:2000814; GO:0030307; GO:2000147; GO:0060999; GO:2000784; GO:0051894; GO:0010592; GO:1904783; GO:1905873; GO:0045862; GO:0031915; GO:0006606; GO:0006468; GO:0022604; GO:0061001; GO:0014823; GO:0043200; GO:0014070; GO:0009615