ATF1 | Cyclic AMP-dependent transcription factor ATF-1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
ATF1
Synonyms
-
Protein Name
Cyclic AMP-dependent transcription factor ATF-1
UniProt ID
P18846 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000262053
NCBI Gene ID
466
Molecular Weight
29233
Protein Length
271
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Gene Ontology
GO:1990590; GO:0005654; GO:0005634; GO:0005667; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0046982; GO:0044877; GO:0000977; GO:0034622; GO:0045740; GO:0010976; GO:0045944; GO:0032025; GO:0014070
 
Gene Ontology