CaMKinet | Result

Gene

LIG1

Synonyms

Protein Name

DNA ligase 1

UniProt ID

P18858 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000263274

NCBI Gene ID

3978

Molecular Weight

101736

Protein Length

919

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1x9n)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

6.5.1.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.

Localization

Nucleus;

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Gene Ontology

GO:0005737; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0005524; GO:0003677; GO:0003910; GO:0003909; GO:0046872; GO:0009653; GO:0006284; GO:0051301; GO:0071897; GO:0006266; GO:0051103; GO:0006310; GO:0006281; GO:0006273; GO:0006298; GO:0006297; GO:1903461; GO:0006283