Protein Name
Glutamate receptor 4
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
100758
Protein Length
902
Protein Domain
3D Structure
(PDB ID : 3en3)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell junction,Synapse,Postsynaptic cell membrane,Cell projection,Dendrite;
Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
Gene Ontology
GO:0032281; GO:0030054; GO:0030425; GO:0043197; GO:0098978; GO:0099061; GO:0008328; GO:0032983; GO:0043025; GO:0005886; GO:0014069; GO:0045202; GO:0043195; GO:0004971; GO:0042802; GO:0004970; GO:0007268; GO:0050804; GO:0051968; GO:0050803; GO:0060992