CDK11B | Cyclin-dependent kinase 11B
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CDK11B
Synonyms
CDC2L1 CDK11 PITSLREA PK58
Protein Name
Cyclin-dependent kinase 11B
UniProt ID
P21127 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000464016
NCBI Gene ID
984
Molecular Weight
92620
Protein Length
795
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.22; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
Gene Ontology
GO:0005737; GO:0005634; GO:0005524; GO:0004693; GO:0004672; GO:0004674; GO:0003723; GO:0006915; GO:0008283; GO:0000278; GO:0006468; GO:0001558; GO:0050684; GO:0006355