Protein Name
Oxysterol-binding protein 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
89421
Protein Length
807
Protein Domain
3D Structure
(PDB ID : 2rr3)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytosol,Cytoplasm,Perinuclear region,Golgi apparatus membrane,Endoplasmic reticulum membrane,Golgi apparatus,trans-Golgi network;
Function
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
Gene Ontology
GO:0030054; GO:0005737; GO:0005829; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0097038; GO:0048471; GO:0005886; GO:0005802; GO:0008289; GO:0008142; GO:0070273; GO:0019904; GO:0032934; GO:0015248; GO:0006699; GO:0032367; GO:0044128; GO:0015918