Grm1 | Metabotropic glutamate receptor 1
 
Sequence Viewer
Gene
Grm1
Synonyms
Gprc1a Mglur1
Protein Name
Metabotropic glutamate receptor 1
UniProt ID
P23385 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSRNOP00000047790
NCBI Gene ID
24414
Molecular Weight
133236
Protein Length
1199
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1ewk)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane;
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Gene Ontology
GO:0030424; GO:0043197; GO:0098978; GO:0005887; GO:0099061; GO:0099055; GO:0014069; GO:0098839; GO:0042734; GO:0030331; GO:0004930; GO:0099530; GO:0008066; GO:0042802; GO:0099583; GO:0001639; GO:0019722; GO:0007268; GO:0007216; GO:0007186; GO:0051899; GO:0007206; GO:0051482; GO:0014048; GO:0051966; GO:0019233; GO:0051932
 
Gene Ontology