CaMKinet | Result

Gene

JAK1

Synonyms

JAK1A JAK1B

Protein Name

Tyrosine-protein kinase JAK1

UniProt ID

P23458 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000343204

NCBI Gene ID

3716

Molecular Weight

133277

Protein Length

1154

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3eyh)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.10.2; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Localization

Endomembrane system;

Function

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).

Gene Ontology

GO:0005737; GO:0005856; GO:0005829; GO:0005768; GO:0005925; GO:0016020; GO:0005634; GO:0005524; GO:0031730; GO:0005131; GO:0046872; GO:0004715; GO:0019903; GO:0004713; GO:0005088; GO:0031625; GO:0019221; GO:0060333; GO:0035722; GO:0035723; GO:0038110; GO:0038114; GO:0070106; GO:0070757; GO:0070102; GO:0038111; GO:0038113; GO:0035556; GO:0000165; GO:1903672; GO:0006468; GO:0060334; GO:0046677; GO:0060337