CaMKinet | Result

Gene

CFL1

Synonyms

CFL

Protein Name

Cofilin-1

UniProt ID

P23528 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000309629

NCBI Gene ID

1072

Molecular Weight

18502

Protein Length

166

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1q8g)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus matrix,Cytoplasm,Cytoskeleton,Cell projection,Ruffle membrane,Cell projection,Lamellipodium membrane,Cell projection,Lamellipodium;

Function

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).

Gene Ontology

GO:0005911; GO:0030864; GO:0005737; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0030027; GO:0031258; GO:0016020; GO:0016363; GO:0005634; GO:0032587; GO:0031982; GO:0051015; GO:0005102; GO:0030036; GO:0030042; GO:0030043; GO:0007010; GO:0030010; GO:0035722; GO:0000281; GO:0043066; GO:0001755; GO:0001842; GO:0044794; GO:0030836; GO:0006468; GO:0022604; GO:0061001; GO:0043200; GO:0009615; GO:0007266