Protein Name
Brain-derived neurotrophic factor
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
27818
Protein Length
247
Protein Domain
3D Structure
(PDB ID : 1b8m)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Gene Ontology
GO:0030424; GO:0005737; GO:0031410; GO:0030425; GO:0005576; GO:0005615; GO:0005739; GO:0016607; GO:0048471; GO:0008021; GO:0008083; GO:0007202; GO:0007411; GO:0031547; GO:0048668; GO:0007613; GO:0050804; GO:0010832; GO:0043524; GO:0021675; GO:0038180; GO:0007399; GO:0048812; GO:0048011; GO:0007422; GO:0031550; GO:0048672; GO:1903997; GO:1900122; GO:0051965; GO:0045664; GO:2000008; GO:0007416; GO:0007169