Protein Name
DNA replication licensing factor MCM3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
90981
Protein Length
808
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Gene Ontology
GO:0005658; GO:0005813; GO:0042555; GO:0016020; GO:0000784; GO:0005654; GO:0005634; GO:0048471; GO:0005524; GO:0003677; GO:0004386; GO:0006260; GO:0006270; GO:0000082