DNAJB1 | DnaJ homolog subfamily B member 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
DNAJB1
Synonyms
DNAJ1 HDJ1 HSPF1
Protein Name
DnaJ homolog subfamily B member 1
UniProt ID
P25685 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000254322
NCBI Gene ID
3337
Molecular Weight
38044
Protein Length
340
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1hdj)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Nucleus,Nucleus,Nucleolus;
Function
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Gene Ontology
GO:0005737; GO:0005829; GO:0043197; GO:0070062; GO:0098978; GO:0043025; GO:0005730; GO:0005654; GO:0005634; GO:0014069; GO:0061827; GO:0001671; GO:0051117; GO:0045296; GO:0051087; GO:0030544; GO:0003714; GO:0051082; GO:0051085; GO:0030900; GO:0090084; GO:0000122; GO:0097201; GO:0032781; GO:1900034; GO:0006986
 
Gene Ontology