CaMKinet | Result

Gene

NFKBIA

Synonyms

IKBA MAD3 NFKBI

Protein Name

NF-kappa-B inhibitor alpha

UniProt ID

P25963 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000216797

NCBI Gene ID

4792

Molecular Weight

35609

Protein Length

317

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1ikn)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Nucleus;

Function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Gene Ontology

GO:0005737; GO:0005829; GO:0033256; GO:0005622; GO:0005654; GO:0005634; GO:0005886; GO:0019899; GO:0042802; GO:0051059; GO:0008139; GO:0008134; GO:0031625; GO:0006915; GO:0070417; GO:0007253; GO:0042994; GO:0007249; GO:0070498; GO:0031663; GO:0043066; GO:0043392; GO:0010888; GO:0010745; GO:0045638; GO:0032088; GO:0045746; GO:0070427; GO:0070431; GO:0032270; GO:0010875; GO:0050729; GO:0045944; GO:0016579; GO:0042127; GO:1901222; GO:0043330; GO:0032495; GO:0035994; GO:0034142; GO:0033209; GO:0016032