Function
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).
Gene Ontology
GO:0005911; GO:0005801; GO:0005737; GO:0005829; GO:0016020; GO:0043005; GO:0005634; GO:1990578; GO:0005942; GO:0005943; GO:0005886; GO:0032991; GO:0016303; GO:0046935; GO:0051117; GO:0005516; GO:0043125; GO:0030331; GO:0043559; GO:0005158; GO:0043560; GO:0005159; GO:0005168; GO:0035014; GO:0036312; GO:0051219; GO:0001784; GO:0005161; GO:0008022; GO:0019904; GO:0046982; GO:0019901; GO:0019903; GO:0030971; GO:0005102; GO:0008134; GO:0031625; GO:0030183; GO:0001678; GO:0032869; GO:0034644; GO:0008625; GO:0006006; GO:0060396; GO:0008286; GO:0048009; GO:0008630; GO:0043066; GO:0045776; GO:0007162; GO:0022408; GO:0001953; GO:0010459; GO:0010656; GO:0045671; GO:0045861; GO:0048662; GO:0014065; GO:0046854; GO:0030335; GO:1900103; GO:0010628; GO:0045663; GO:0042307; GO:0001934; GO:0033120; GO:0045944; GO:0032760; GO:0006606; GO:0006468; GO:0050821; GO:0046626; GO:0043551; GO:1903076; GO:0051492; GO:0051591; GO:0034976; GO:0051384; GO:0032868