Protein Name
MAP/microtubule affinity-regulating kinase 3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
84429
Protein Length
753
Protein Domain
3D Structure
(PDB ID : 3fe3)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cell membrane,Cell projection,Dendrite,Cytoplasm;
Function
Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
Gene Ontology
GO:0005737; GO:0005829; GO:0030425; GO:0070062; GO:0005886; GO:0005524; GO:0004674; GO:0048156; GO:0050321; GO:0030010; GO:0035556; GO:0000165; GO:0000226; GO:0035331; GO:0036289; GO:0018105; GO:0032092; GO:0006468