PDE4A | cAMP-specific 3',5'-cyclic phosphodiesterase 4A
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PDE4A
Synonyms
DPDE2
Protein Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
UniProt ID
P27815 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000293683
NCBI Gene ID
5141
Molecular Weight
98143
Protein Length
886
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2qyk)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.4.53; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
3',5'-cyclic AMP + H2O = AMP + H(+)
Localization
Isoform 1: Cytoplasm,Perinuclear region;Isoform 2: Cytoplasm,Perinuclear region,Cell projection,Ruffle membrane;Isoform 4: Membrane;Isoform 6: Cytoplasm,Perinuclear region;Isoform 7: Cytoplasm,Membrane;
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Ontology
GO:0005829; GO:0016020; GO:0005654; GO:0048471; GO:0005886; GO:0032587; GO:0004115; GO:0030552; GO:0046872; GO:0006198; GO:0035690; GO:0007186; GO:0043949; GO:0010738; GO:0007608; GO:0007165
 
Gene Ontology