CaMKinet | Result

Gene

DUSP1

Synonyms

CL100 MKP1 PTPN10 VH1

Protein Name

Dual specificity protein phosphatase 1

UniProt ID

P28562 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000239223

NCBI Gene ID

1843

Molecular Weight

39298

Protein Length

367

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 6apx)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

3.1.3.16; 3.1.3.48; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphateH2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphateH2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Localization

Nucleus;

Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Gene Ontology

GO:0005737; GO:0005634; GO:0019838; GO:0017017; GO:0051019; GO:0004722; GO:0004725; GO:0008138; GO:0008330; GO:1990869; GO:0032870; GO:0000188; GO:0035556; GO:0071850; GO:0043066; GO:0007162; GO:0008285; GO:2000279; GO:0070373; GO:0043407; GO:0043409; GO:0051447; GO:0090027; GO:1903753; GO:0070262; GO:0035970; GO:0035335; GO:0043065; GO:0090266; GO:0051592; GO:0051591; GO:0032355; GO:0051384; GO:0042542; GO:0009416; GO:0032526; GO:0033574