CaMKinet | Result

Gene

NOS3

Synonyms

Protein Name

Nitric oxide synthase, endothelial

UniProt ID

P29473 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

NCBI Gene ID

Molecular Weight

133287

Protein Length

1205

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1d0c)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

1.14.13.39; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide

Localization

Cell membrane,Membrane,Caveola,Cytoplasm,Cytoskeleton,Golgi apparatus;

Function

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Gene Ontology

GO:0005901; GO:0005856; GO:0005829; GO:0005794; GO:0005634; GO:0005886; GO:0012506; GO:0005516; GO:0050660; GO:0010181; GO:0020037; GO:0046872; GO:0050661; GO:0003958; GO:0004517; GO:0016491; GO:0006527; GO:0007596; GO:0071499; GO:0007005; GO:0045776; GO:1902042; GO:1903038; GO:0006809; GO:0007263; GO:0031284; GO:0009725; GO:0032496