Protein Name
Nitric oxide synthase, endothelial
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
133275
Protein Length
1203
Protein Domain
3D Structure
(PDB ID : 1m9j)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide
Localization
Cell membrane,Membrane,Caveola,Cytoplasm,Cytoskeleton,Golgi apparatus;
Function
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Gene Ontology
GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0030666; GO:0005794; GO:0000139; GO:0005634; GO:0005886; GO:0012506; GO:0003785; GO:0034618; GO:0046870; GO:0005516; GO:0050660; GO:0010181; GO:0020037; GO:0050661; GO:0003958; GO:0004517; GO:0016491; GO:0097110; GO:0034617; GO:0001525; GO:0003180; GO:0006527; GO:0001974; GO:0045454; GO:0051186; GO:0003203; GO:0043542; GO:0048873; GO:0001701; GO:0031663; GO:0030324; GO:0007005; GO:0070168; GO:0045776; GO:0051926; GO:0008285; GO:1902042; GO:0051346; GO:0014740; GO:0010544; GO:0043267; GO:0006809; GO:0007263; GO:0001542; GO:0045766; GO:0043536; GO:0010628; GO:0031284; GO:0003184; GO:0008217; GO:0050880; GO:0031644; GO:0050999; GO:0002028; GO:0003100; GO:0003057; GO:0019430; GO:0034405; GO:0009408; GO:0009725; GO:0032496; GO:0014806; GO:0042311; GO:0060412