Protein Name
Nitric oxide synthase, brain
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
160559
Protein Length
1429
Protein Domain
3D Structure
(PDB ID : 1b8q)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide
Localization
Cell membrane,Sarcolemma,Cell projection,Dendritic spine;
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
Gene Ontology
GO:0042582; GO:0005737; GO:0005829; GO:0030425; GO:0043197; GO:0098978; GO:0016020; GO:0005741; GO:0005739; GO:0031965; GO:0005634; GO:0048471; GO:0001917; GO:0005886; GO:0014069; GO:0099092; GO:0099091; GO:0032991; GO:0042383; GO:0030141; GO:0045202; GO:0012506; GO:0051117; GO:0046870; GO:0005516; GO:0019899; GO:0050660; GO:0010181; GO:0020037; GO:0044325; GO:0050661; GO:0070402; GO:0003958; GO:0004517; GO:0016491; GO:0051219; GO:0042803; GO:0097110; GO:0017080; GO:0008270; GO:0007568; GO:0006527; GO:0048148; GO:0007420; GO:0071872; GO:0071260; GO:0045184; GO:0007565; GO:0043066; GO:0045776; GO:0008285; GO:0051481; GO:0045822; GO:0061875; GO:0046676; GO:0034760; GO:0043524; GO:0033137; GO:0045906; GO:0006809; GO:0007263; GO:0018119; GO:0097755; GO:0031284; GO:1900273; GO:1901216; GO:1902307; GO:0008016; GO:0051930; GO:0014823; GO:0043627; GO:0045471; GO:0009408; GO:0009725; GO:0001666; GO:0010288; GO:0032496; GO:0035094; GO:0071731; GO:0031667; GO:0014070; GO:0010243; GO:0043434; GO:0033197; GO:0098924