Protein Name
Wee1-like protein kinase
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
71597
Protein Length
646
Protein Domain
3D Structure
(PDB ID : 5vd9)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Gene Ontology
GO:0005737; GO:0005730; GO:0005654; GO:0005634; GO:0005524; GO:0016301; GO:0000287; GO:0004715; GO:0004672; GO:0004713; GO:0051301; GO:0030010; GO:0000086; GO:0000226; GO:0007093; GO:2000134; GO:0048812