CDC25B | M-phase inducer phosphatase 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
CDC25B
Synonyms
CDC25HU2
Protein Name
M-phase inducer phosphatase 2
UniProt ID
P30305 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000245960
NCBI Gene ID
994
Molecular Weight
64987
Protein Length
580
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1cwr)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.3.48; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Localization
Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoskeleton,Spindle pole;
Function
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Gene Ontology
GO:0005813; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0000922; GO:0004721; GO:0019901; GO:0004725; GO:0051301; GO:0007144; GO:0000086; GO:0000278; GO:0001556; GO:0008284; GO:0032467; GO:0010971; GO:0110032; GO:0045931; GO:0045860; GO:0006468
 
Gene Ontology