CDC25C | M-phase inducer phosphatase 3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CDC25C
Synonyms
-
Protein Name
M-phase inducer phosphatase 3
UniProt ID
P30307 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000321656
NCBI Gene ID
995
Molecular Weight
53365
Protein Length
473
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2ojx)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.3.48; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Localization
Nucleus;
Function
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
Gene Ontology
GO:0005737; GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0048471; GO:0004721; GO:0019901; GO:0004725; GO:0050699; GO:0051301; GO:0008283; GO:0006977; GO:0000086; GO:0010971; GO:0110032; GO:0045931; GO:0000079; GO:0007088; GO:0007283; GO:0016032
 
Gene Ontology