Protein Name
Sodium-dependent serotonin transporter
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
70325
Protein Length
630
Protein Domain
3D Structure
(PDB ID : 5i6x)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Endomembrane system,Endosome membrane;
Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Gene Ontology
GO:0005829; GO:0012505; GO:0010008; GO:0005887; GO:0099055; GO:0099056; GO:0045121; GO:0043005; GO:0005886; GO:0099154; GO:0051015; GO:0019811; GO:0046872; GO:0008504; GO:0017022; GO:0050998; GO:0042803; GO:0017137; GO:0051378; GO:0005335; GO:0017075; GO:0048854; GO:0071321; GO:0071300; GO:0007623; GO:0007613; GO:0015844; GO:0021941; GO:0045665; GO:0046621; GO:0032227; GO:0042136; GO:0045787; GO:0010628; GO:0014064; GO:0051259; GO:0051260; GO:0090067; GO:0042493; GO:0032355; GO:0001666; GO:0007584; GO:0009636; GO:0006837; GO:0051610; GO:0035176; GO:0042713; GO:0042310