L1CAM | Neural cell adhesion molecule L1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
L1CAM
Synonyms
CAML1 MIC5
Protein Name
Neural cell adhesion molecule L1
UniProt ID
P32004 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000355380
NCBI Gene ID
3897
Molecular Weight
140003
Protein Length
1257
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane,Cell projection,Growth cone,Cell projection,Axon,Cell projection,Dendrite;
Function
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Gene Ontology
GO:0030424; GO:0044295; GO:0009986; GO:0062023; GO:0030425; GO:0005925; GO:0016021; GO:0043025; GO:0005886; GO:0008046; GO:0019904; GO:0061564; GO:0007411; GO:0007155; GO:0016477; GO:0007160; GO:0006935; GO:0007156; GO:0050900; GO:0007399; GO:0031175; GO:0045773; GO:0050808