TTK | Dual specificity protein kinase TTK
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
TTK
Synonyms
MPS1 MPS1L1
Protein Name
Dual specificity protein kinase TTK
UniProt ID
P33981 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000230510
NCBI Gene ID
7272
Molecular Weight
97072
Protein Length
857
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 4jt3)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.12.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Function
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
Gene Ontology
GO:0005737; GO:0000776; GO:0016020; GO:0005819; GO:0005524; GO:0043515; GO:0042803; GO:0004674; GO:0004712; GO:0004713; GO:0051304; GO:0016321; GO:0033316; GO:0007094; GO:0007052; GO:0018105; GO:0018107; GO:0008284; GO:0010862; GO:0046777; GO:0034501; GO:1903096; GO:0007051
 
Gene Ontology