Protein Name
DNA replication licensing factor MCM5
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
82286
Protein Length
734
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
Localization
Nucleus,Cytoplasm,Cytosol;
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.
Gene Ontology
GO:0005829; GO:0042555; GO:0016020; GO:0000784; GO:0005654; GO:0005634; GO:0005524; GO:0003688; GO:0004386; GO:0006260; GO:0006270; GO:0000082