CaMKinet | Result

Gene

SPR

Synonyms

Protein Name

Sepiapterin reductase

UniProt ID

P35270 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000234454

NCBI Gene ID

6697

Molecular Weight

28048

Protein Length

261

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1z6z)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

1.1.1.153; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH

Localization

Cytoplasm;

Function

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Gene Ontology

GO:0005829; GO:0070062; GO:0005654; GO:0004033; GO:0050661; GO:0004757; GO:0051186; GO:0006809; GO:0055114; GO:0050999; GO:0006729