CaMKinet | Result

Gene

IRS1

Synonyms

Protein Name

Insulin receptor substrate 1

UniProt ID

P35568 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000304895

NCBI Gene ID

3667

Molecular Weight

131591

Protein Length

1242

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1irs)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Function

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Gene Ontology

GO:0005901; GO:0005737; GO:0005829; GO:0005899; GO:0043231; GO:0005634; GO:0005886; GO:0016303; GO:0005158; GO:0005159; GO:0043548; GO:0046934; GO:0001784; GO:0005080; GO:0005088; GO:0042169; GO:0005070; GO:0005068; GO:0032869; GO:0042593; GO:0008286; GO:0048009; GO:0038111; GO:0000165; GO:0046627; GO:0046676; GO:0014065; GO:0048015; GO:0008284; GO:0032000; GO:0046326; GO:0010907; GO:0045725; GO:0046628; GO:0043552; GO:0051897; GO:0032868; GO:0043434; GO:0007165