Irs1 | Insulin receptor substrate 1
 
Sequence Viewer
Gene
Irs1
Synonyms
Irs-1
Protein Name
Insulin receptor substrate 1
UniProt ID
P35570 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
25467
Molecular Weight
131178
Protein Length
1235
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5wrk)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Function
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Gene Ontology
GO:0005737; GO:0005829; GO:0005899; GO:0043231; GO:0005634; GO:0005886; GO:0005158; GO:0005159; GO:0043548; GO:0019904; GO:0019901; GO:0005080; GO:0042169; GO:0005068; GO:0007568; GO:1904385; GO:1990416; GO:0071478; GO:0008286; GO:0048009; GO:0046627; GO:0046676; GO:0090275; GO:0070094; GO:0046628; GO:0043552; GO:0042327; GO:0051291; GO:0014823; GO:0031000; GO:0043434
 
Gene Ontology