ADD2 | Beta-adducin
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
ADD2
Synonyms
ADDB
Protein Name
Beta-adducin
UniProt ID
P35612 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000264436
NCBI Gene ID
119
Molecular Weight
80854
Protein Length
726
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Cytoskeleton,Cell membrane;
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
Gene Ontology
GO:0031410; GO:0005856; GO:0005829; GO:0008290; GO:0044853; GO:0014069; GO:0003779; GO:0051015; GO:0005516; GO:0046982; GO:0042803; GO:0019901; GO:0030507; GO:0005198; GO:0030036; GO:0051017; GO:0051016; GO:0030097; GO:0050900; GO:0050901; GO:0032092; GO:0065003; GO:0007416; GO:0055085
 
Gene Ontology