Function
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling.
Gene Ontology
GO:1990622; GO:1990617; GO:0036488; GO:0005737; GO:0005770; GO:0005634; GO:0032993; GO:0008140; GO:0003677; GO:0001228; GO:0003700; GO:0043522; GO:0046982; GO:0042803; GO:0000978; GO:0008134; GO:0044212; GO:0000976; GO:0006915; GO:0001955; GO:0007050; GO:0045454; GO:0030968; GO:0006983; GO:0072655; GO:0070059; GO:1990442; GO:0042789; GO:0090090; GO:0120163; GO:0032792; GO:2000016; GO:0043392; GO:0043433; GO:0045599; GO:0045662; GO:0051898; GO:1903026; GO:0000122; GO:0045892; GO:0043065; GO:0034263; GO:0051091; GO:0032757; GO:0043525; GO:1901216; GO:0045944; GO:1990440; GO:0045893; GO:0043161; GO:0051259; GO:0044324; GO:0006355; GO:0051209; GO:0034976; GO:0042594; GO:0006986; GO:0016055