CaMKinet | Result

Gene

MAP2K2

Synonyms

MEK2 MKK2 PRKMK2

Protein Name

Dual specificity mitogen-activated protein kinase kinase 2

UniProt ID

P36507 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000262948

NCBI Gene ID

5605

Molecular Weight

44424

Protein Length

400

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1s9i)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.12.2; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cytoplasm,Membrane;

Function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

Gene Ontology

GO:0005911; GO:0005737; GO:0009898; GO:0005829; GO:0005769; GO:0005783; GO:0005576; GO:0005925; GO:0005794; GO:0005770; GO:0005874; GO:0005739; GO:0005634; GO:0048471; GO:0005778; GO:0005524; GO:0004708; GO:0046872; GO:0030165; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0000187; GO:0032147; GO:0070371; GO:0000165; GO:0010629; GO:0036289; GO:1903800; GO:0071902; GO:0045893; GO:2000641; GO:0090170; GO:0032872; GO:0023014; GO:0031098