Gene
Synonyms
CD135 FLK2 STK1
Protein Name
Receptor-type tyrosine-protein kinase FLT3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
112903
Protein Length
993
Protein Domain
3D Structure
(PDB ID : 3qs7)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Localization
Membrane,Endoplasmic reticulum lumen;
Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Gene Ontology
GO:0005829; GO:0005783; GO:0005788; GO:0005887; GO:0005634; GO:0005886; GO:0043235; GO:0016303; GO:0005524; GO:0004896; GO:0035259; GO:0042803; GO:0043621; GO:0044877; GO:0005088; GO:0004714; GO:0005021; GO:0031100; GO:0030183; GO:0071345; GO:0071385; GO:0035726; GO:0019221; GO:0097028; GO:0002244; GO:0030097; GO:0002521; GO:0001776; GO:0030098; GO:0046651; GO:0000165; GO:0002318; GO:0018108; GO:0008284; GO:0070374; GO:0043406; GO:0043410; GO:0043552; GO:0014068; GO:0042531; GO:0002328; GO:0046777; GO:0042981; GO:0010243; GO:0007169; GO:0016032