CaMKinet | Result

Gene

SREBF1

Synonyms

BHLHD1 SREBP1

Protein Name

Sterol regulatory element-binding protein 1

UniProt ID

P36956 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000261646

NCBI Gene ID

6720

Molecular Weight

121675

Protein Length

1147

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1am9)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle,COPII-coated vesicle membrane;Processed sterol regulatory element-binding protein 1: Nucleus;Isoform SREBP-1aDelta: Nucleus;Isoform SREBP-1cDelta: Nucleus;

Function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

Gene Ontology

GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0012507; GO:0000139; GO:0016021; GO:0005635; GO:0005654; GO:0005634; GO:0032991; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0008047; GO:0004879; GO:0046983; GO:0019901; GO:0044877; GO:0000977; GO:0032810; GO:0007568; GO:0071398; GO:0009267; GO:0008203; GO:0007623; GO:0045444; GO:0008286; GO:0008610; GO:0006629; GO:0030324; GO:0042789; GO:0046676; GO:0000122; GO:0045542; GO:0031065; GO:1902895; GO:0045944; GO:0010867; GO:1903146; GO:0045540; GO:0019217; GO:0003062; GO:0031647; GO:1903214; GO:0006357; GO:0051591; GO:0032094; GO:0033762; GO:0009749; GO:0032570; GO:0032526