STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cytoplasm,Membrane,Nucleus,Cell junction,Synapse,Secreted;

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).

GO:0015629; GO:0030424; GO:0005938; GO:0030054; GO:0005737; GO:0005829; GO:0005576; GO:0005615; GO:0005794; GO:0030426; GO:0016234; GO:0005764; GO:0016020; GO:0005743; GO:0005758; GO:0005759; GO:0005741; GO:0005739; GO:0043025; GO:0005640; GO:0005634; GO:0048471; GO:0005886; GO:0098794; GO:0005840; GO:0005791; GO:0099512; GO:0030672; GO:0043195; GO:0003779; GO:0043014; GO:0048487; GO:0005509; GO:0005507; GO:1903136; GO:0043027; GO:0070840; GO:0008198; GO:0042393; GO:0030544; GO:0042802; GO:0019894; GO:0000287; GO:0008017; GO:0016491; GO:0043274; GO:0005543; GO:0051219; GO:0019904; GO:0047485; GO:0000149; GO:0048156; GO:0044212; GO:0008270; GO:0006919; GO:0008344; GO:0007568; GO:0048148; GO:0044267; GO:0071280; GO:0071872; GO:0044344; GO:0034599; GO:0042416; GO:0051583; GO:0060079; GO:0006631; GO:0060291; GO:0001774; GO:0042775; GO:0007006; GO:0043066; GO:1904715; GO:0043154; GO:0045963; GO:0051585; GO:0045920; GO:0035067; GO:0031115; GO:1902957; GO:0032769; GO:0043524; GO:1901215; GO:0051622; GO:0010642; GO:0001933; GO:0051612; GO:0070495; GO:0000122; GO:0032410; GO:0006638; GO:0055114; GO:0006644; GO:0043065; GO:0045807; GO:0045921; GO:1903284; GO:1903285; GO:0050729; GO:0060732; GO:1901216; GO:0001956; GO:0033138; GO:0071902; GO:0001921; GO:0051281; GO:0031648; GO:0051262; GO:0031623; GO:0050812; GO:0014059; GO:0014048; GO:0040012; GO:0048169; GO:0043030; GO:0051621; GO:0010517; GO:1905606; GO:1903426; GO:1903421; GO:0022898; GO:1904307; GO:0034341; GO:0070555; GO:0010040; GO:0032496; GO:0032026; GO:0035493; GO:0097435; GO:0050808; GO:0048488; GO:0016079