ATP6V1A | V-type proton ATPase catalytic subunit A
 
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Sequence Viewer
Gene
ATP6V1A
Synonyms
ATP6A1 ATP6V1A1 VPP2
Protein Name
V-type proton ATPase catalytic subunit A
UniProt ID
P38606 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000273398
NCBI Gene ID
523
Molecular Weight
68304
Protein Length
617
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
7.1.2.2; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate
Localization
Cytoplasm;
Function
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857).
Gene Ontology
GO:0016324; GO:0005829; GO:0070062; GO:0005765; GO:0005902; GO:0005886; GO:0016469; GO:0033180; GO:0005774; GO:0005524; GO:0046961; GO:0015991; GO:0046034; GO:0006879; GO:0036295; GO:0008286; GO:0034220; GO:0016241; GO:0033572