Gene
Synonyms
CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
Protein Name
Cyclin-dependent kinase inhibitor 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
18119
Protein Length
164
Protein Domain
3D Structure
(PDB ID : 1axc)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus;
Function
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Gene Ontology
GO:0000307; GO:0005829; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0070557; GO:0048471; GO:0032991; GO:0030332; GO:0019912; GO:0004693; GO:0004861; GO:0046872; GO:0019901; GO:0004860; GO:0044877; GO:0031625; GO:0031100; GO:0007050; GO:0034198; GO:0006974; GO:0031668; GO:0034605; GO:0071479; GO:0071493; GO:0090398; GO:0019221; GO:0006977; GO:0000082; GO:0000086; GO:0007507; GO:0060574; GO:0097193; GO:0071850; GO:0043066; GO:1905179; GO:0030308; GO:0008285; GO:1904030; GO:2000134; GO:0042326; GO:1904706; GO:0010942; GO:0048146; GO:0045860; GO:2000379; GO:0050821; GO:0007265; GO:0000079; GO:0006357; GO:0090399; GO:0046685; GO:0051412; GO:0042493; GO:0055093; GO:0010243; GO:0009636; GO:0010165; GO:0090400; GO:0006367