Protein Name
Cyclin-dependent kinase inhibitor 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
17785
Protein Length
159
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus;
Function
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity).
Gene Ontology
GO:0000307; GO:0005737; GO:0005829; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0070557; GO:0048471; GO:0032991; GO:0030332; GO:0019912; GO:0004693; GO:0004861; GO:0046872; GO:0019901; GO:0004860; GO:0044877; GO:0031625; GO:0007050; GO:0034198; GO:0006974; GO:0031668; GO:0071480; GO:0071479; GO:0071493; GO:0090398; GO:0006977; GO:0006978; GO:0000082; GO:0000086; GO:0007507; GO:0042771; GO:0071850; GO:0043066; GO:1905179; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:2000134; GO:0010629; GO:0042326; GO:1904706; GO:0030890; GO:0010942; GO:0048146; GO:0043068; GO:0045860; GO:2000379; GO:0051726; GO:0000079; GO:2000278; GO:0007346; GO:0009411; GO:0042246