Protein Name
Flap endonuclease 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
42593
Protein Length
380
Protein Domain
3D Structure
(PDB ID : 1u7b)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Localization
Isoform 1: Nucleus,Nucleolus,Nucleus,Nucleoplasm;Isoform FENMIT: Mitochondrion;
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Gene Ontology
GO:0016020; GO:0005739; GO:0000784; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0008409; GO:0017108; GO:0003684; GO:0003677; GO:0003690; GO:0008309; GO:0004519; GO:0004527; GO:0048256; GO:0000287; GO:0030145; GO:0004523; GO:0006284; GO:0006281; GO:0006260; GO:0043137; GO:0006302; GO:0000724; GO:0007613; GO:0090305; GO:0045876; GO:0032201; GO:0009650