CaMKinet | Result

Gene

VHL

Synonyms

Protein Name

von Hippel-Lindau disease tumor suppressor

UniProt ID

P40337 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000256474

NCBI Gene ID

7428

Molecular Weight

24153

Protein Length

213

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1lm8)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Isoform 1: Cytoplasm,Membrane,Nucleus;Isoform 3: Cytoplasm,Nucleus;

Function

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

Gene Ontology

GO:0005829; GO:0005783; GO:0016020; GO:0005739; GO:0005654; GO:0005634; GO:0030891; GO:0019899; GO:0008134; GO:0061630; GO:0004842; GO:0000902; GO:0043066; GO:0008285; GO:0010629; GO:0046426; GO:0000122; GO:0061428; GO:0045597; GO:0045893; GO:0043687; GO:0050821; GO:0016567; GO:0006508; GO:0061418; GO:0006355