Protein Name
60S ribosomal protein L13a
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
23577
Protein Length
203
Protein Domain
3D Structure
(PDB ID : 4ug0)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Gene Ontology
GO:0005737; GO:0005829; GO:0022625; GO:0005925; GO:0097452; GO:0015934; GO:0016020; GO:0005730; GO:0005634; GO:1990904; GO:0005840; GO:0003729; GO:0003723; GO:0003735; GO:0071346; GO:1901194; GO:0017148; GO:0000184; GO:0006614; GO:0006412; GO:0006413