Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
Gene Ontology
GO:0005737; GO:0005829; GO:0098978; GO:0005743; GO:0000790; GO:0005654; GO:0005634; GO:0005886; GO:0014069; GO:0090575; GO:0098685; GO:0005667; GO:0031730; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0035259; GO:0042802; GO:0004879; GO:0046983; GO:0042803; GO:0019901; GO:0019903; GO:0000978; GO:0001103; GO:0008134; GO:0044212; GO:0006953; GO:0007568; GO:0048708; GO:0008283; GO:0071345; GO:0032870; GO:0044320; GO:0071407; GO:0019221; GO:0042755; GO:0097009; GO:0001754; GO:0042593; GO:0060396; GO:0060397; GO:0006954; GO:0035723; GO:0038114; GO:0038155; GO:0070106; GO:0070757; GO:0070102; GO:0038111; GO:0038113; GO:0030522; GO:0033210; GO:0035278; GO:0050804; GO:0042789; GO:0043066; GO:0010507; GO:0008285; GO:0045820; GO:0010730; GO:1901215; GO:2001223; GO:2000737; GO:0000122; GO:0007399; GO:0016310; GO:0045766; GO:2001171; GO:0030335; GO:0045648; GO:0010628; GO:2000637; GO:1902728; GO:0045410; GO:1904685; GO:0051092; GO:0045747; GO:1902895; GO:0045944; GO:0045893; GO:0042531; GO:1905564; GO:0099527; GO:0006606; GO:0060019; GO:0007259; GO:0051726; GO:0060259; GO:0046902; GO:0040014; GO:0006357; GO:0006355; GO:0032355; GO:0045471; GO:0044321; GO:0019953; GO:0007165; GO:0035019; GO:0072540; GO:0001659; GO:0016032