SLC1A3 | Excitatory amino acid transporter 1
 
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Sequence Viewer
Gene
Synonyms
EAAT1 GLAST GLAST1
Protein Name
Excitatory amino acid transporter 1
UniProt ID
P43003 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
59572
Protein Length
542
Protein Domain
3D Structure
(PDB ID : 5llm)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Catalytic Activity
-
Localization
Cell membrane;
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Gene Ontology
GO:0009986; GO:0005887; GO:0016020; GO:0043005; GO:0043025; GO:0005886; GO:0015171; GO:0016595; GO:0015501; GO:0005314; GO:0005313; GO:0046872; GO:0031223; GO:0048667; GO:0007268; GO:1902476; GO:0021545; GO:0070779; GO:0009449; GO:0006537; GO:0014047; GO:0006811; GO:0140009; GO:0051938; GO:0098712; GO:0015813; GO:0050885; GO:0001504; GO:0050806; GO:0071805; GO:0046677; GO:0009416; GO:0009611; GO:0007605
 
Gene Ontology