STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Chromosome,Nucleus,Nucleus,Nucleolus;

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

GO:0005694; GO:0016020; GO:0016604; GO:0005730; GO:0005634; GO:0005524; GO:0003677; GO:0008022; GO:0003723; GO:0007049; GO:0008283; GO:1902275; GO:0051983; GO:0007088