Protein Name
Transcription factor GATA-4
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
44597
Protein Length
440
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).
Gene Ontology
GO:0016604; GO:0005634; GO:0090575; GO:0033613; GO:0070410; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001158; GO:0051525; GO:0019901; GO:0000978; GO:0001085; GO:0043565; GO:0003713; GO:0008134; GO:0044212; GO:0008270; GO:0003180; GO:0003290; GO:0055007; GO:0048738; GO:0061049; GO:0071333; GO:0003197; GO:0007507; GO:0060575; GO:0008584; GO:0010507; GO:0030513; GO:0045944; GO:0045893; GO:0086004; GO:0006355; GO:0042493; GO:0009612; GO:0033189; GO:0060290